Hoxa2plays a direct role in murine palate development
نویسندگان
چکیده
منابع مشابه
Role of skeletal muscle in palate development.
The involvement of skeletal muscle in the process of palatal development in mammals is an example of Waddingtonian epigenetics. Our earlier study showed that the cleft palate develops in the complete absence of skeletal musculature during embryonic development in mice. This contrasts with previous beliefs that tongue obstruction prevents the elevation and fusion of the palatal shelves. We argue...
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In palatogenesis, the MEE (Medial Edge Epithelium) cells disappear when palates fuse. We hypothesize that the MEE cells undergo EMT (Epithelial-Mesenchymal Transition) to achieve mesenchyme confluence. Twist has an important role in EMT for tumor metastasis. The purpose of this study was to analyze Twist function during palatal fusion. Twist protein was expressed in palatal shelves and MEE both...
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Joshua Weiner et al. demonstrate that cadherin-related -protocadherins are directly involved in synaptic development. This gene cluster has been suspected to be involved in synaptic specificity, but functional tests of this idea were lacking. Previous research from their group showed that mice lacking the cluster of the three protocadherin (Pcdh) gene clusters ( , , and ) had decreased spinal c...
متن کاملSignaling networks in palate development.
UNLABELLED Palatogenesis, the formation of the palate, is a dynamic process regulated by a complex series of context-dependent morphogenetic signaling events. Many genes involved in palatogenesis have been discovered through the use of genetically manipulated mouse models as well as from human genetic studies, but the roles of these genes and their products in signaling networks regulating pala...
متن کاملA dosage-dependent role for Spry2 in growth and patterning during palate development
The formation of the palate involves the coordinated outgrowth, elevation and midline fusion of bilateral shelves leading to the separation of the oral and nasal cavities. Reciprocal signaling between adjacent fields of epithelial and mesenchymal cells directs palatal shelf growth and morphogenesis. Loss of function mutations in genes encoding FGF ligands and receptors have demonstrated a criti...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2009
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.22040